MAGNESIUM –PICRATE COMPLEXES AS COUPLING AGENTS TO ENHANCE UV-VISIBLE SPECTROPHOTOMETRIC DRUG ANALYSIS

Abstract

This research investigates the production of magnesium-picrate complexes and their use as coupling agents to improve UV-Visible spectrophotometric detection and quantification of vital medicinal medicines. The analyzed pharmaceuticals comprise Diclofenac Sodium, Ciprofloxacin HCl, Levoceitrizine 2HCl, Levofloxacin Hemihydrate, Nimesulide, Piroxicam BCD, and Terbinafine HCl. The synthesized magnesium-picrate complexes, upon heating with medication solutions, exhibited substantial increases in absorbance at their specific characteristic wavelengths. The increases were documented as 70.82%, 47.95%, 64.11%, 64.05%, 39.24%, 81.16%, and 87.10%, respectively, reflecting increased molar absorptivity. The 90% yield of magnesium-picrate complexes and their capacity to improve spectrum detection highlight their promise in optimizing UV-Visible spectrophotometric techniques for pharmaceutical quality assurance.